This setting does break GHub force feedback for older games that don't have built in support for force feedback - if your wheel needs this setup for Forza and you want to play older games, you are going going to need separate profiles. At this point, my wheel is working properly and force feedback can be setup in Forza Horizon 4.
Same issue using a Thrustmaster TX Italia, that works perfectly on my One X, but the series X it is set to 270 degrees and will not allow me to change it and there is no force feedback until you tune the wheel 90degrees and makes driving damned near impossible. Spend the greater part of 4 hours trying to get this to work.
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forza horizon 4 wheel settings thrustmaster